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Specifically, it is characterized by decreased expression levels of Bcl-2 and Bcr/Abl, disruption of mitochondrial membrane potential, and increased levels of Bax, cytochrome c , and cleaved caspase-3

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Moreover, it is worth to underline the need of exploring the role of iron-mediated oxidative damage through Fenton reaction to further ascertain the contribution of mitochondrial dysfunction and iron accumulation to the progression and pathologic development of age-related diseases

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GHK-Cu works gradually through cumulative collagen and elastin stimulation