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Lauren Mitchell, Pharmacist (US)

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In the second subgroup (ALC add-on vs the same background drug), Gavrilova et al 19 observed AEs in 35% with ALC add-on versus 45% with antidepressant alone, and Ramezani et al 20 reported AEs in three patients (1 in ALC + sertraline, 2 in sertraline + placebo)

Researchers have shown interest in these compounds for areas including: Cellular signaling Metabolic pathways Recovery and tissue biology Mitochondrial function Inflammatory pathways Exercise physiology The advisory committees recommendation reflects growing debate about how these substances should be regulated

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