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Biotin deficiency is rare but can occur in specific groups: High-Risk Groups: People with metabolic disorders or malnutrition Alcoholics and athletes Epilepsy patients , elderly , and those with gastrointestinal surgery Pregnant women (studies show 50% develop deficiency due to increased vitamin demand) Diabetes patients Dietary Causes: Long-term consumption of raw egg whites contains avidin , a protein that binds biotin and prevents absorption

None of the studies cited above controlled for where the women or animals were during the menstrual (or estrus) cycle when the measurements were made

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