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It could be isolated or be the first manifestation of vitamin deficiency and occur without any haematological or gastrointestinal context

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10.1016/S0140-6736(99)00569-3 Lancet 36 OliveiraK

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We have taken advantage of the ease with which ligand complexes can be produced in GR crystals, a property that extends to the isomorphous GRTR crystals, and have produced and analyzed crystals of GRTR complexes with glutathione, trypanothione, glutathionylspermidine and of a true catalytic intermediate, the mixed disulfide between trypanothione and the enzyme