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There is some thought that since Pycnogenol can improve endothelial function and reduce catecholamine excess, it might actually mitigate some physical side effects of stimulants (like if a stimulant raises heart rate, Pycnogenol might blunt that increase a bit by improving vascular function)

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For example, those with severe liver or kidney impairment, unstable heart disease, or other significant systemic illnesses are typically approached carefully if considering NAD+ therapy

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The genetic test does not predict your exact response to either medication class