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Notably, when canine osteosarcoma cells D17 were treated with BI2536, the number of cells was reduced from 20%2.4% to 7.4%2% in the G0/G1 phase and increased from 18.3%2.4% to 47.2%7.7% in the G2/M phase, decreasing cell viability by up to 61.2% (P 20 H2AX foci by 59% and 107%, respectively 18 (Table 1)

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The peptide upregulates VEGF expression in multiple cell types and enhances endothelial cell responses to VEGF signaling

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