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To determine the robustness of the screen the statistical parameter, Z-prime (Z) was determined (25) and at 40 hours of growth the values obtained were very significant (for Screen I =0.95 and for Screen II = 0.91) which suggested that the screens we developed were robust and would be compliant for a high throughput setting (Figure S6)

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showed that resistin bound directly to TLR4 and increased CCL4 expression in NP cells via the p38-MAPK and NF-B pathways, which ultimately led to macrophage infiltration

Furthermore, PINK1/Parkin mediates PARIS degradation through ubiquitylation, which in turn is involved in the regulation of mitochondrial biogenesis (Lee H

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