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In a rat model of adjuvant-induced arthritis, the combination of metformin (200 mg/kg/day) and omega-3 (300 mg/kg/day) showed efficacy comparable to methotrexate (2 mg/kg/week) in ameliorating disease activity, with significant reductions in arthritic scores, paw swelling, and serum TNF- and IL-1 after 4 weeks (252)

Evidence regarding the impact of parenteral L-carnitine supplementation on apnea incidence is currently mixed

Molecules (Basel, Switzerland) 15(3):18731881 Joseph JM, Sowndhararajan K, Manian S (2010) Protective effects of methanolic extract of Hedyotis puberula (G

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