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Sanders also recommends two go-tos: "Microneedling and/or radiofrequency treatments will also tighten lax skin, and the use of fillers to provide necessary soft tissue support is also helpful." On the derm front, Dallas dermatologist Elizabeth Houshmand, MD is seeing it, too, and calls out this interesting study, published by Dermatology Times , which holds promising results for these specific patients: "A novel skin-care treatment has been developed for patients with reduced facial skin quality due to the use of Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and SGLT-2 inhibitors

J Tgeor Biol 142:201221 Jones DP, Liang Y (2009) Measuring the poise of thiol/disulfide couples in vivo

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10.1002/ijc.28749 222 WangQ.HardieR

They work through integrated actions on your pancreas, gut-brain axis and multiple organs including the liver, heart, kidney and brain