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The DSIP-CBBBP group, in particular, showed superior improvement over both the model and DSIP-only groups, suggesting enhanced efficacy of the fusion peptide

& Kinsella, L

In susceptible patients, these pressures may increase mitochondrial stress, raise SAH, lower the SAM-to-SAH ratio and create a functional undermethylation pattern that contributes to depression, anxiety, brain fog, fatigue and medication sensitivity

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Altered intestinal permeability (leaky gut) allows the passage of food antigens, toxins, bacteria, and microbial products, promoting inflammation and dysregulated immune responses, triggering autoimmunity through various mechanisms [188]