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The thioesterase (TE) domain is able to release the target peptide by either hydrolysis or cyclization 12,15,16 and is supposed to condense tetradepsipeptides, first to produce an octadepsipeptidyl- O -TE and then a decadepsipeptidyl- O -TE, followed by macrolactonization to form the cyclic twelve residue product cereulide 8,9

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"The structure of apo human glutamate dehydrogenase details subunit communication and allostery"

If an intestinal obstruction is not treated, it could cause death of the surrounding intestinal tissue and infection of the abdominal cavity (peritonitis)

162 TMAO may accelerate the progression or rupture of abdominal aortic aneurysm by inducing VSMC apoptosis through the activation of PERK-mediated UPR