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Higenamine is documented to be a constituent of the plant Tinospora crispa , which can be found in some dietary supplements

Helps to add gloss to skin and may visually fill in fine lines/wrinkles for short time Helps attract water to the upper layer of the skin and improves the product texture A peptide that can help neutralize free radicals in skin and reduce melanin production resulting in skin lightening effect and reduction in hyperpigmentation

Cytotoxicity detection Cytotoxicity was detected by the LDH assay (Roche, 4744926001)

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Even the approved 4g/day dose for two weeks can raise liver enzyme levels in about a third of patients