Iron metabolism can regulate ferroptosis via a variety of methods
The same effect could be observed with a 2-week des-fluoro-sitagliptin treatment leading to increased insulin exocytosis by cells from db / db diabetic mice (133)
Mills BJ, Weiss MM, Lang CA, Liu MC, Ziegler C (2000) Blood glutathione and cysteine changes in cardiovascular disease
AC system activation generates an increase of the intracellular secondary messenger, cyclic adenosine monophosphate (cAMP), through the conversion of adenosine triphosphate, which then results in the activation of protein kinase A (PKA) and exchange protein activated by cAMP (Epac) [32,33,34,35]
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