Wegovy carries precautionary warnings about thyroid C-cell tumours based on animal studies, though no causal link is established in humans
Novo Nordisk has recently received praise because after the end of the shortage it announced that it is introducing a direct-to-consumer program that offers a monthly price of $499 for Wegovy if purchased without insurance
Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [9-, 33- and 113- fold the maximum recommended human dose (MRHD) of RYBELSUS 14 mg, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (3-, 9- and 33-fold MRHD) were administered to the females
NICEs 2025 guidance calls this dual-agonist action, the first of its kind approved in the UK
Prolactin in man: A tale of two promoters