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"Heavy Metal-Induced Changes in the Glutathione Levels and Glutathione Reductase/Glutathione S-Transferase Activities in the Liver of Male Mice." Journal of Toxicology and Environmental Health

Accessed 24 June 2024

Deficiency vs

While acute iron exposure produced minimal biochemical changes and did not sensitize cells to oxidative or ferroptotic challenges, chronic iron exposure induced ferritin upregulation, mitochondrial superoxide accumulation, suppression of GPX4 expression, elevated lipid peroxidation and loss of cellular glutathione (GSH)