Last October, a 42-year-old project manager named Daniel in Austin told me something I've heard dozens of times now: "I wasn't expecting to feel the sleep thing so fast." He'd started a no-DAC CJC-1295 + ipamorelin protocol at 100 mcg and 200 mcg respectively, injecting subcutaneously before bed
Over time, that effect fades, but the appetite suppressing effects in the brain stick around
Despite the controversies about the expression of GLP-1R in vascular smooth muscle and endothelial cells, studies have shown that GLP-1RAs have anti-proliferative effects on these cells, and also reduced oxidative stress and increased the production of nitric oxide (NO) (137, 138)
10.1007/s00401-015-1449-5 Acta Neuropathol
Higher doses around 500-1000mg are used for skin health, anti-aging, and other therapeutic benefits