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A post hoc analysis of data from SURPASS-4 showed that tirzepatide is effective in reducing the risk of worsening renal function compared with insulin glargine

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The higher vascularity of muscle tissue approximately 45 times greater capillary density than subcutaneous fat accounts for this difference

While the sum of measured bile acids was not increased in PBH versus asymptomatic participants in this cohort, the conjugated bile acid taurocholate was 2.5-fold higher in PBH in the fasting state, consistent with prior reports (9, 11), and several species tended to be higher in post-surgical participants