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Furthermore, intestinal I/R injury can activate the vagus nerve, transmitting signals to the brain that influence neuronal activity and cognitive function, and alter gut microbial metabolite production, such as short-chain fatty acids (SCFAs), thus affecting neuronal signaling and cognitive processes (Wu et al., 2021

Gonzalez, D.F

The FDA recently recognized this methods value by approving fixed-dose combination products (like Advil Dual Action), which combine both drugs in a single tablet

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doi: 10.3390/cells9020305 16 ZhangQHeYLuoNPatelSJHanYGaoRet al