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The observed risk for metformin-induced vitamin B 12 deficiency demonstrated an additive effect for rs1801222 genotype, with both AG (OR 1.37 [95% CI 1.21, 1.54], I 2 =18.6%) and AA (OR 2.30 [95% CI 1.99, 2.65], I 2 =0%) genotype groups being at increased risk vs the GG group

Often there are associations and correlations found but its rare and extremely exciting to find something that actual a direct effect

While GHK-Cu is naturally occurring, the effects of supplementation during these periods haven't been studied

Writing review and editing, ML, WL, and YZ

Tips for patients Here are some tips for patients before starting treatment: Keep monitoring your energy levels, B12 levels, and any neuropathy symptoms