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As in the previous recommendations by the ADA and EASD (73, 74), life-style intervention (with patient education and motivation, increase of physical activity, and healthy eating) is still in the beginning and center of therapy, followed by pharmacological therapy with metformin (7074)

However, berberine and blood sugar-lowering supplements should be used cautiously due to additive hypoglycemia risk

Circularity and sustainability are pivotal in these transitions, offering transformative approaches to managing resources, fostering resilience, and creating more equitable urban systems

The long-term safety profile remains a question mark, and pharmacy availability is years away

STEP 2 Meet With Provider Have a virtual 1-on-1 with a licensed provider, at your convenience, to review your health history, evaluate your labs, explore treatments, and set goals