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Our real-world evidence of the comparative effectiveness of GLP-1RAs versus insulin complements existing trial evidence by translating the efficacy of GLP-1RAs in clinical trials to its effectiveness in clinical practice among a broader spectrum of real-world patient populations for supporting the rational selection of GLAs in clinical practice [48]

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Previous studies of linagliptin have demonstrated improvement in HOMA-, insulinogenic index and oral disposition index ( At the end of the study, both HOMA-IR and TyG index were significantly improved in the high GLP-1 group of the T2D population