Interestingly, direct injections of Ex-4 into the gustatory cortex of mice maintained on a high-fat diet reduced intake only when the fat density of the test diet differed from that of the maintenance diet, regardless of whether the shift was from high- to low-fat or low- to high-fat relative to the maintenance diet
GLP-1 is an incretin hormone that is secreted in response to food intake, and it exerts multiple actions conducive to glycemic control, including enhancing glucose-dependent insulin secretion, suppressing glucagon release, and delaying gastric emptying [39]
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Acquisition of novel gene function, such as the roles of GLP-1 and insulin variants in venom, is generally thought to occur through gene duplication followed by functional diversification