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Votes were tied to the question of whether those bulk substances should be placed on the 503A Bulks List

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The change from baseline in the composite score was calculated as the difference between the composite score at the end of study (EOS) and the baseline (BL) composite score (Comp = CompEOS CompBL)

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18 Table 4 Time to Improvement of Abnormalities in Vitamin B12 Deficiency After Initiation of Treatment A 2005 Cochrane review involving 108 patients with vitamin B 12 deficiency found that high-dose oral replacement (1 mg to 2 mg per day) was as effective as parenteral administration for correcting anemia and neurologic symptoms