The only study to report a significant increase in plasma homocysteine in children with autistic disorder [74] was not replicated by the same research group using a fasted sample [60]
Most of the GSH used for detoxification is produced in the liver and excreted in plasma in the blood stream
BSO is an inhibitor of GSH synthase that has been used to deplete GSH in vitro , including in macrophages ( We analyzed the gene expression profile and identified patterns of LPS-induced genes that were inhibited by endogenous GSH or that, on the contrary, required GSH for their induction
Proc Natl Acad Sci 89:444448 Kolesnik B, Palten K, Schrammel A, Stessel H, Schmidt K, Mayer B, Gorren AC (2013) Efficient nitrosation of glutathione by nitric oxide
The incomplete processing of toxins may produce dangerous free radicals