A 40 is induced by an increase in intracellular Ca 2+ , and this has led to the hypothesis that the accumulation of intracellular A may occur as an early event in the pathogenesis of AD (Itkin et al., 2011)
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Another finding was that some GLP-1 agonists crossed the blood-brain barrier more quickly than others, supporting the idea that a centrally acting mechanism is involved in the effect of GLP-1 agonists on alcohol seeking behavior
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The ROS-mediated damage is further enhanced in older individuals since during aging, GSH levels appear to diminish in numerous tissues, thereby placing cells at increased risk of stress-related death (Maher, 2005)
