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The column temperature was set to 40 C, and the gradient elution was at 0.35 mL/mL of flow rate: 0 to 3 min, linear gradient from 15% to 70% of Phase A

Histopathological analysis and immunohistochemical staining revealed decreased expression of K16, K17, and Ki67 in SFN-treated mice, indicating reduced abnormal differentiation of keratinocytes and cutaneous inflammation

Some patients experience minimal digestive disruption, while others report significant gastrointestinal symptoms that may affect treatment adherence and quality of life

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