Oleocanthal and inflammation
In this review, we explore the complex interplay between sleep, metabolism, and aging across five core themes: (1) the role of sleep in maintaining optimal free radical levels, (2) whether ROS directly contribute to or mediate sleep disturbances in aging, (3) how age-related sleep disturbances may, in turn, contribute to impaired brain metabolism and exacerbate age-related changes, (4) the role of sleep, redox, and aging in peripheral systems, and (5) the evidence that improving mitochondrial redox potential restores sleep and slows aging, as well as the potential benefits of interventions like exercise, antioxidant-rich foods, supplements, and specialized diets that enhance sleep and/or metabolic efficiency, and their effects on aging markers (summarized in Figure 1)
A 12-week randomized controlled trial in vegans and vegetarians with marginal deficiency (Effect of two different sublingual dosages of vitamin B12 on cobalamin nutritional status, Del Bo and colleagues, Clinical Nutrition , 2018, 40 subjects) found that even a modest sublingual dose of about 50 mcg per day restored serum B12 and improved holotranscobalamin, methylmalonic acid, and homocysteine, which confirms that sublingual liquid B12 can correct a marginal deficiency in plant-based eaters
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The rectal body temperatures of 10-day-old JVS mice were significantly lower than those of control animals (Table 1)
