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The elevated expression of 20S proteasome (increased PSMA6), which play an important role in the elimination of oxidized proteins, might be one of the mechanisms that account for reduced levels of oxidized proteins in male livers

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Importantly, these self-reacting copper and sulfur redoxomes also interact with each other through the prominent chelation of Cu(I) by thiols of either the antioxidant copper chaperone protein Atox1 or GSH [63, 142, 160,161,162]

This gives your body a chance to stabilize NAD metabolism and avoid unnecessary adaptation or receptor downregulation