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However, the efficacy of D + Q and other senolytics has shown variability across models and contexts, with inconsistent effects on senescence markers and limited evidence of lifespan extension in more rigorous or genetically diverse preclinical settings 38 , underscoring potential influences of dosing, genetic background, or model differences 27

Diabetes Care 41 , 613619 (2018)

Future research priorities include: - Safety in Diverse Populations: Large-scale trials are needed to establish the long-term safety and efficacy of dual receptor agonists in special populations, including patients with type 1 diabetes and pregnant women

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