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In pancreatic -cells, uric acid triggers ERK activation, resulting in reduced cell viability, apoptosis, and the production of reactive oxygen species

pylori therapy (Boonyaritichaikij et al

CPP-CAND disrupts FOXO4-p53 foci and induces apoptosis through caspase-dependent pathways FOXO4 is progressively recruited to euchromatin foci following senescence induction and is retained in the nucleus of senescent cells through its interaction with p53, contributing to the maintenance of the senescent state 34

doi: 10.3389/fphys.2023.1281071 Received 21 August 2023 Accepted 16 October 2023 Published 31 October 2023 Volume 14 - 2023 Edited by Maria Cavinato, University of Innsbruck, Austria Reviewed by Eleni Mavrogonatou, National Centre of Scientific Research Demokritos, Greece Raghvendra K

Think of oxidative stress as a form of biological "rust" that can wear down your cells over time