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Conditioning inclusion on documented weight loss may also introduce collider bias if women who successfully lost weight differ systematically in motivation, adherence, or metabolic responsiveness

For non-diabetic individuals struggling with obesity, these medications can support significant weight loss , with clinical trials showing an average reduction of 10-15% of body weight while also improving metabolic health and blood sugar regulation

Whilst it does not directly increase fertility, the significant weight loss it can produce may indirectly restore ovulation in women with conditions such as polycystic ovary syndrome (PCOS) or obesity-related infertility

Tirzepatide may be considered when a patient wants a medication with strong average weight-loss results and is medically appropriate for treatment

When used for weight loss, Semaglutide injections help people feel fuller for longer, leading to reduced calorie intake