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But for researchers with pre-existing conditions, those extra beats raise real questions about monitoring, dose adjustment, and long-term safety that deserve thorough answers

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Dyer AH, et al

When a small group of patients began taking a very tiny dose starting at 0.0675 mg, compared to the label-recommended 0.25 mg and increased it gradually, they were able to tolerate it better than the folks who started the usual dose and tried to escalate it in the typical way, says Alkhaddo