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Along with the heterogeneity of the disease and the lack of reliable biomarkers, the problem for developing specific treatments for PD is its multiple pathophysiological mechanisms, many of which are common to the mechanisms of T2DM development, including brain insulin resistance, impaired energy and glucose metabolism, mitochondrial dysfunction, chronic systemic inflammation, neuroinflammation, impaired lysosome function, and oxidative stress [56, 57]

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Over-the-Counter Options and Medical Guidance If lifestyle and dietary changes are not enough to manage the discomfort, there are over-the-counter (OTC) options that may help

Glossary Organotypic cultures Cell culture systems prepared from slices of neonatal or early postnatal brain, in which the general synaptic and circuit architecture is preserved