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Clinicians might need to adjust laxative dosage to prevent constipation or overly delayed gastric emptying, balancing the effects to maintain symptom relief in IBS-C patients

The hHPN RS mutant was engineered to produce hepsin without functional activity by introducing two specific mutations in critical regions of its proteolytic activity

Understanding why this occurs, how common it is, and effective management strategies can help patients navigate this side effect while continuing treatment

The opportunity was real, but so were the long-term sustainability questions

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