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Glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide (marketed under the highly recognizable brand names Ozempic and Wegovy ) and dual GIP/GLP-1 receptor agonists like tirzepatide (Mounjaro, Zepbound) have demonstrated exceptional clinical efficacy for glycemic control, sustainable weight loss, and altering the surgical approach to global obesity

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These approaches may be particularly relevant for patients with cirrhosis, in whom psychiatric comorbidities including depression and anxiety are prevalent and contribute to the pain experience [1]