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Anatomic Sites Sites for subcutaneous injections include the outer lateral aspect of the upper arm, the abdomen (from below the costal margin to the iliac crest and more than two inches from the umbilicus), the anterior upper thighs, the upper back, and the upper ventral gluteal area

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While native IGF-1 within physiological ranges appears safe, supraphysiological stimulation of IGF-1 receptor signaling through exogenous administration of potent analogs like IGF-1 DES could theoretically promote growth of existing pre-malignant or malignant cells, accelerate tumor progression, or support metastatic spread by enhancing cell survival and proliferation while inhibiting apoptosis