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Although rigorous propensity score matching was applied to reduce confounding, residual confounding from unmeasured variables (e.g., lifestyle factors, socioeconomic status, over-the-counter medication use) cannot be excluded

The longest of the trials (SURMOUNT-4) reported weight loss of -20.9% within 36 weeks and an additional -5.5% (total of -25.4%) within 88 weeks of administration [20]

This will reduce the protection provided by the HPA axis, attenuating immune and inflammatory changes, and leaving ME/CFS patients more vulnerable to minor stressors (429)

But carrying one is strongly recommended

The study one of seven trials planned found orforglipron is just as safe as other GLP-1 drugs, with the similar side effects like diarrhea and nausea