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Time-to-effect varies by compound and outcome

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Evidence in women is even more limited than in men, and pregnancy and breastfeeding are absolute contraindications

Referral to clinical genetics or endocrinology may be appropriate for individuals with concerning family histories to guide treatment decisions

Doses up to 600 mg were generally well-tolerated with no clinically significant abnormalities in blood pressure or heart rate, no observed skin pigmentation, and no significant changes to adrenal, urinary or hematology panels