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A solution to induce an acute hepatic toxicity and a rapidly progressing encephalopathy with severe seizures in rats may be a single paracetamol overdose (5 g/kg intraperitoneally) that excided the regimens previously used (1, 2, 6, 11)

The median time of onset of this severe reaction was 3 weeks ( In Indonesia, allopurinol as a xanthine inhibitor is the first line of drugs in the management of gout arthritis to lower uric acid levels ( However, allopurinol is recognized as one of the main causes of SCARs, including SJS and TEN

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however, in the normal person the excretion step is the slowest, and therefore the rate-limiting, step

10.1074/jbc.M111177200 113