Glutamate and -KG serve as important exchangers in the MAS, and since GLS1 knockdown significantly suppresses NADH and ATP production in cancer cells 143 , the supply of glutamate and -KG for the induction of MAS activity is evidently critical for ATP production in cancer cells (Fig
Autoantibodies stimulate thyroid cells to produce excess thyroid hormones, leading to hyperthyroidism (64, 133, 139)
However, only 41.8% stayed on treatment at 6 months 109 , in line with the available literature reporting disappointingly low adherence to liraglutide for obesity management and raising concerns about its role in the lifelong challenge of BW control and weight-related complications 110
What is the cost-effectiveness in real life, given the much lower adherence and the high stopping rates, and what are the possible consequences? For more information: Reimar W ernich Thomsen , MD, PhD, can be reached at [email protected] or on LinkedIn @ReimarWThomsen.
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