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Glutamate and -KG serve as important exchangers in the MAS, and since GLS1 knockdown significantly suppresses NADH and ATP production in cancer cells 143 , the supply of glutamate and -KG for the induction of MAS activity is evidently critical for ATP production in cancer cells (Fig

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Autoantibodies stimulate thyroid cells to produce excess thyroid hormones, leading to hyperthyroidism (64, 133, 139)

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However, only 41.8% stayed on treatment at 6 months 109 , in line with the available literature reporting disappointingly low adherence to liraglutide for obesity management and raising concerns about its role in the lifelong challenge of BW control and weight-related complications 110

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What is the cost-effectiveness in real life, given the much lower adherence and the high stopping rates, and what are the possible consequences? For more information: Reimar W ernich Thomsen , MD, PhD, can be reached at [email protected] or on LinkedIn @ReimarWThomsen.

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