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In contrast, dopamine and serotonin levels were reduced compared to the healthy population, which could underline the diffuse pain sensation and discomfort [16]

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It has been speculated that oxidative stress as well as mitochondrial damage may act together in inducing neurodegeneration

Hence the observed increase in GSH activity (total and reduced glutathione) in the magnesium treated diabetic animals may possibly be due to its effect on the enzymes gamma glutamyl transpeptidase (GGT), glutamate cysteine ligase and glutathione synthetase respectively