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The pharmacokinetics of 2-O-methyl phosphorothioate antisense oligonucleotides: experiences from developing exon skipping therapies for duchenne muscular dystrophy

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For instance, in NSCLC cells, elevated lactylation of histone H3 reduces glycolysis and maintains mitochondrial balance by altering mRNA levels of glycolytic enzymes ( HK1, PKM ) and TCA cycle enzymes ( SDHA, IDH3G ), highlighting the crosstalk between histone Kla and glucose metabolism in cancer progression