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(2014) showed that indole affects L-cells in two distinct ways: short-term exposure acutely stimulate GLP-1 production by inhibiting K+ channels and altering the action potential of L-cells, while long-term exposure inhibits mitochondrial metabolism, leading to a reduced concentration of ATP in L-cells and subsequent reduction in GLP-1 secretion 64

Collectively, these findings suggest that composite dietary fiber may alleviate obesity-induced muscle atrophy through structural and functional remodeling of the gut microbiota, potentially by enriching beneficial taxa and inhibiting harmful ones, thereby contributing to the restoration of myometabolic homeostasis

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