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At the highest dose, roughly 10.5% average body-weight reduction at 26 weeks, about 11.8% at 36 weeks, vs ~0.30.6% on placebo
It says to tell your provider promptly rather than accepting reflux as inevitable, and lists what a provider might consider, including a lower strength, slower escalation, timing changes, or temporary discontinuation
Office workers in Bengaluru and Mumbai, in particular, report better adherence with a "with breakfast" habit than a strict empty-stomach one, simply because mornings are rushed
Similar improvements in body weight loss and clinical disease were seen with a lower (1.42 mg/kg) and a higher (5.68 mg/kg) dose of PG-CAT (Supplementary Fig
It often disrupts sleep
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