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Acknowledgements The authors thank the research resource division (RRD) (RIKEN Center for Brain Science) and RIKEN CBS-EVIDENT Open Collaboration Center (RIKEN Center for Brain Science) for technical assistance, Yukiko Nagai (RIKEN Center for Brain Science) for secretarial work, Kenichi Nagata (Nagoya University) and members of the Laboratory for Proteolytic Neuroscience (RIKEN Center for Brain Science) for beneficial suggestions

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Elsevier, Amsterdam, pp 375394 Hum DW, Bell AW, Rozen R, MacKenzie RE (1988) Primary structure of a human trifunctional enzyme

Antioxidant and Tissue Protection Copper is required for the function of several key antioxidant enzymes, including superoxide dismutase

These effects contribute to improved skin structure and wound repair, making it an area of interest in aesthetic and regenerative dermatology research