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It stimulates ACTH and cortisol release (likely through hypothalamic CRH activation), increases prolactin secretion, and potently stimulates appetite through ghrelin-mimetic activity at the GHS-R1a receptor in the arcuate nucleus

Preclinical studies show GHK-Cu is active at very low doses in animals (approximately 0.5 mcg/kg in rodent models) [15] , while clinical practice employs milligram-range dosing in humans to achieve systemic effects [5] [6]

Interactions of iron, dopamine and neuromelanin pathways in brain aging and Parkinsons disease