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That is normal in obesity and diabetes treatment, and it is one reason dose titration and medical review matter

To evaluate spermatogenesis and male fertility in mice, Computer-Aided Sperm Motion Analysis (CASA) was conducted on epididymal sperm to determine motility parameters, including the percentage of motile and forward progressive sperm

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Zhang X, Li LX, Ding H, Torres VE, Yu C, Li X

The ferroptosis activator RSL3 increases the sensitivity of prostate cancer cells to cisplatin by producing ROS, aggravating cell cycle arrest and apoptosis caused by cisplatin [42]