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Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a Tethering mechanism: a TWO-SITE INTERACTION MODEL FOR THE Nrf2-Keap1 COMPLEXA TWO-SITE INTERACTION MODEL FOR THE Nrf2-Keap1 COMPLEX

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Lactate inhibits the deacetylase SIRT1 through Hippo/YAP-mediated lactylation and G protein-coupled receptor 81-dependent -arrestin2-mediated recruitment of p300/CBP in the nucleus, driving HMGB1 acetylation