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Case reports and case series have documented instances of severe, persistent gastroparesis temporally associated with GLP-1 initiation, with some patients requiring hospitalization for refractory nausea and vomiting

Rare cases of allergic skin reactions have been reported with GLP-1 use, including urticaria (hives), rash, and pruritus (itching)

AMPK-sensing energy while talking to other signaling pathways

While there is no direct interaction with semaglutide itself, patients on diuretics, ACE inhibitors, or those with chronic kidney disease should avoid regular use of magnesium laxatives

Proc Nutr Soc 2017;76:427-36