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El GLP-1R se encuentra en mltiples tejidos perifricos como pncreas, intestino, rin, tejido mamario, pulmn, corazn y cerebro 19,20 , mediando la activacin de la protena cinasa A (PKA) o del factor intercambiador de nucletidos de guanina regulador por AMPc (EPAC) (Figura 2) 21

The GLP-1 receptor activation slows gastric emptying, reduces appetite, and improves insulin sensitivity

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